Upcoming Events
  1. ALTG open MAC and SAC meetings

    November 20
  2. Virtual 2020 World Conference on Lung Cancer Singapore

    January 28, 2021 @ 8:00 am - January 31, 2021 @ 5:00 pm

Thoracic oncology highlights from ASCO2020 webinar- recording and evaluation survey

Please fill in the evaluation survey if you have not already done so by clicking on the survey icon at the base of your webinar console.

Please access the recording and evaluation survey here

ALTG awarded $12 million in funding

The ALTG is pleased to announce over $12 million in funding has been successfully awarded to ALTG, NHMRC Clinical Trial Centre and the Australian Genomic Cancer Medicine Centre for the ASPiRATION project. In this ground-breaking precision medicine study, led by ALTG President A/Prof Nick Pavlakis and ALTG Scientific Advisory Committee Chair, Prof Ben Solomon, ASPiRATION will explore the benefit of routine comprehensive genomic profiling in 1000 newly-diagnosed metastatic, non-squamous, NSCLC patients in Australia. The enhanced genomic profiling will assist in personalising patient care by matching patients to targeted treatments as early as possible to improve patient outcomes.


Elections for the Management Advisory Committee (MAC) close on 12th May at the ALTG Members’ Meeting in Melbourne – we are seeking a MAC Secretary and representatives for Allied Health/Nursing, Medical Oncology and Palliative Care. Contact enquiries@altg.com.au for more information.

The first patient has been enrolled into NIVORAD– congratulations to the team at Royal Brisbane and Women’s Hospital – pictured, from L to R: Brett Hughes (PI), Erin Purdon (CT Coordinator), Rob McDowall (Radiation Therapist Consultant – Planning) and Philip Chan (Radiation Oncology Consultant)!

NIVORAD (ALTG 14/002) is a phase 2 placebo-controlled randomised study of nivolumab ± radiotherapy in the treatment of advanced NSCLC and will open at 25 sites in total; site activation is ongoing. This is a valuable opportunity for patients with advanced NSCLC to have access to nivolumab. See our Trials pages for more details.

With successful completion of the safety run-in period, full recruitment to DREAM (ALTG 15/004) has also commenced and is progressing rapidly, with 15/31 patients enrolled in Stage 1. Site activation is ongoing for the 14 sites that will ultimately be open. DREAM is an opportunity for patients with mesothelioma to receive immunotherapy combined with first-line chemotherapy. See our Trials pages for more details.

The DREAM team: PI Prof Anna Nowak with the team from the National Centre for Asbestos Related Diseases (NCARD) who will perform correlative analyses in the study

NIVORAD and DREAM are part of the AUTO-CHECK study, which has been awarded more than $500,000 through Cancer Australia’s Priority-driven Collaborative Cancer Research Scheme (PdCCRS). The Genomic Cancer Clinical Trial Initiative (GCCTI) worked with several cooperative oncology groups and the CI, Matthew Cook, to develop and submit the successful application for the AUTO-CHECK study: Molecular determinants of autoimmunity and immune related adverse events in advanced cancer patients treated with immune checkpoint inhibitors.

In other trial news:

  • Recruitment to BR.31 (ALTG 14/001; phase 3 placebo controlled randomised study of adjuvant durvalumab in completely resected NSCLC) continues to progress. It is critical for this study that all patients who are being treated surgically are considered for eligibility. This can be best done through the MDT with the support of the lung cancer care coordinator, if available at your site.
  • OSCILLATE (ALTG 16/005; alternating osimertinib and gefitinib in patients with EGFR T790M positive NSCLC) is moving rapidly towards opening for recruitment, with the study submitted for central ethics review in March and site selection currently underway. FPI is planned for Q3 2017.