ALTG 14/001 BR.31: A phase III prospective double blind placebo controlled randomized study of adjuvant MEDI4736 in completely resected non-small cell lung cancer – L Seymour (CCTG), S McLachlan (ALTG)
This multicentre, international trial is being coordinated by the Canadian Cancer Trials Group (CCTG; formerly the NCIC Clinical Trials Group). The study opened to recruitment in late July 2015, with a plan to recruit 200 patients across 25 Australian and 1 New Zealand site over a 3 year period.
This study is looking at the impact of adjuvant therapy with MEDI4736 (AstraZeneca, durvalumab) for one year on the disease free survival of patients with early stage (IB >4cm, II or IIIA) NSCLC that is PD-L1 positive. In ANZ, all sites have been activated and 20 patients have been recruited.
| State/Territory | Site | PI | Activation Date | Recruitment |
|---|---|---|---|---|
| ACT | Canberra Hospital | David Leong | 14 Apr 2016 | |
| NSW | Border Medical Oncology | Craig Underhill | 16 Dec 2016 | |
| Campbelltown Hospital | Po Yee Yip | 16 Dec 2015 | ||
| Central Coast Cancer Centre | Matthew Chan | 1 Oct 2015 | 1 | |
| Chris O'Brien Lifehouse | Steven Kao | 11 Dec 2015 | 1 | |
| Coffs Harbour Health Campus - NCCI | Karen Briscoe | 24 July 2015 | ||
| Liverpool Hospital | Victoria Bray | 20 Nov 2015 | ||
| Nepean Cancer Care Centre | Catherine Crombine | 2 Dec 2015 | 3 | |
| Northern Cancer Institute, St Leonards | Nick Pavlakis | 17 July 2015 | 1 | |
| St George Hospital | Chee Lee | 20 Nov 2015 | ||
| Westmead Hospital | Rina Hui | 17 Jun 2016 | ||
| QLD | Mater Adult Hospital Brisbane | Felicity Murphy (mat. leave), Vikram Jain | 2 Dec 2015 | 2 |
| Nambour General Hospital | Kathleen Houston | 19 Nov 2015 | 1 | |
| Princess Alexandra Hospital | Ken O'Byrne | 10 Sep 2015 | 1 | |
| The Prince Charles Hospital | Brett Hughes | 8 Oct 2015 | 1 | |
| SA | Flinders Medical Centre | Anand Rose | 29 July 2016 | |
| Royal Adelaide Hospital | Michael Brown | 30 July 2015 | 2 | |
| TAS | Royal Hobart Hospital | Louise Nott | 28 Oct 2015 | |
| VIC | Austin Hospital | Shane White | 22 Jan 2016 | |
| Epworth Richmond Hospital | Ross Jennens | 22 July 2015 | ||
| Monash Medical Centre | Peter Briggs | 24 Aug 2016 | ||
| Peninsula Oncology Centre, Frankston | Vinod Ganju | 2 Mar 2016 | ||
| Royal Melbourne Hospital, Parkville | Richard de Boer | 18 Aug 2015 | 1 | |
| St Vincent's Hospital Melbourne including St Vincent's Private Hospital | Sue-Anne McLachlan | 5 Aug 2015 | 3 | |
| WA | Fiona Stanley Hospital | Andrew Davidson | 22 May 2016 | |
| Sir Charles Gairdner Hospital | Michael Millward | 8 Oct 2015 | 3 | |
| Other (NZ) | Canterbury Regional Cancer and Haematology Service | David Gibbs | 19 Nov 2015 |
Study Contacts
Study Chair: Sue-Anne McLachlan sue-anne.mcLachlan@svha.org.au
CTC Trial Coordinator: Hannora Jurkovic BR.31@ctc.usyd.edu.au