ALTG 14/001 BR.31: A phase III prospective double-blind placebo-controlled randomized study of adjuvant MEDI4736 in completely resected non-small cell lung cancer – L Seymour (CCTG), S McLachlan (ALTG)

This multicentre, international trial is being coordinated by the Canadian Cancer Trials Group (CCTG; formerly the NCIC Clinical Trials Group). The study opened in July 2015, with 26 sites in Australia and 1 in New Zealand, recruiting up to 200 patients over a 3 year period.

This study is looking at the impact of adjuvant therapy with MEDI4736 (AstraZeneca, durvalumab) for one year on the disease free survival of patients with early stage (IB >4cm, II or IIIA) NSCLC that is PD-L1 positive. In ANZ, all sites have been activated and 29 patients have been recruited.

State/TerritorySitePIActivation DateRecruitment
ACTCanberra HospitalDavid Leong14 Apr 20161
NSWBorder Medical OncologyCraig Underhill16 Dec 2016
Campbelltown HospitalPo Yee Yip16 Dec 20151
Central Coast Cancer CentreMatthew Chan1 Oct 20151
Chris O'Brien LifehouseSteven Kao11 Dec 20151
Coffs Harbour Health Campus - NCCIKaren Briscoe24 July 2015
Liverpool HospitalVictoria Bray20 Nov 2015
Nepean Cancer Care CentreCatherine Crombine2 Dec 20153
Northern Cancer Institute, St LeonardsNick Pavlakis17 July 20151
St George HospitalChee Lee20 Nov 2015
Westmead HospitalRina Hui17 Jun 2016
QLDMater Adult Hospital BrisbaneFelicity Murphy (mat. leave), Vikram Jain2 Dec 20153
Nambour General HospitalKathleen Houston (maternity leave)
Jeremy Long
19 Nov 20151
Princess Alexandra HospitalKen O'Byrne10 Sep 20151
The Prince Charles HospitalBrett Hughes8 Oct 20152
SAFlinders Medical CentreChris Karapetis29 July 20161
Royal Adelaide HospitalMichael Brown30 July 20152
TASRoyal Hobart HospitalLouise Nott28 Oct 2015
VICAustin HospitalShane White22 Jan 2016
Epworth Richmond HospitalRoss Jennens22 July 20151
Monash Medical CentreMuhammad Alamgeer24 Aug 20162
Peninsula Oncology Centre, FrankstonVinod Ganju2 Mar 2016
Royal Melbourne Hospital, ParkvilleRichard de Boer18 Aug 20152
St Vincent's Hospital Melbourne including St Vincent's Private HospitalSue-Anne McLachlan5 Aug 20153
WAFiona Stanley HospitalAndrew Davidson22 May 2016
Sir Charles Gairdner HospitalMichael Millward8 Oct 20153
Other (NZ)Canterbury Regional Cancer and Haematology ServiceDavid Gibbs19 Nov 2015

Study Contacts

Study Chair: Sue-Anne McLachlan     sue-anne.mcLachlan@svha.org.au

CTC Trial Coordinator: Hannora Jurkovic     BR.31@ctc.usyd.edu.au

Upcoming Events
  1. ***UPDATED*** ALTG Members’ Meeting, Sydney NSW

    November 24
  2. ***UPDATED*** Shine A Light Dinner, Sydney NSW

    November 24 @ 6:00 pm - 9:00 pm AEST
  3. ***UPDATED*** 2017 ALTG Lung Cancer Symposium, Sydney NSW

    November 25 @ 9:00 am - 5:00 pm UTC+10